genome sequence of rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens基因组序列的立克次氏体bellii照亮基因交流的变形虫细胞内病原体的作用.pdfVIP
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genome sequence of rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens基因组序列的立克次氏体bellii照亮基因交流的变形虫细胞内病原体的作用
Genome Sequence of Rickettsia bellii Illuminates the Role of Amoebae in Gene Exchanges between Intracellular Pathogens 1* 2 ´ 1 2 1 2 Hiroyuki Ogata , Bernard La Scola , Stephane Audic , Patricia Renesto , Guillaume Blanc , Catherine Robert , 2 1 2* Pierre-Edouard Fournier , Jean-Michel Claverie , Didier Raoult 1 Structural and Genomic Information Laboratory, Centre National de la Recherche Scientifique UPR-2589, Institut de Biologie Structurale et Microbiologie, Parc Scientifique ´ ´ ´ ´ ´ ´ de Luminy, Marseille, France, 2 Unite des Rickettsies, Centre National de la Recherche Scientifique UMR-6020, IFR-48, Faculte de Medecine, Universite de la Mediterranee, Marseille, France The recently sequenced Rickettsia felis genome revealed an unexpected plasmid carrying several genes usually associated with DNA transfer, suggesting that ancestral rickettsiae might have been endowed with a conjugation apparatus. Here we present the genome sequence of Rickettsia bellii, the earliest diverging species of known rickettsiae. The 1,552,076 base pair–long chromosome does not exhibit the colinearity observed between other rickettsia genomes, and encodes a complete set of putative conjugal DNA transfer genes most similar to homologues found in Protochlamydia amoebophila UWE25, an obligate symbiont of amoebae. The genome exhibits many other genes highly similar to homologues in intracellular bacteria
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