genome sequence of the pathogenic intestinal spirochete brachyspira hyodysenteriae reveals adaptations to its lifestyle in the porcine large intestine基因组序列的致病性肠道螺旋体brachyspira hyodysenteriae揭示了适应其生活方式的猪大肠.pdfVIP

Genome Sequence of the Pathogenic Intestinal Spirochete Brachyspira hyodysenteriae Reveals Adaptations to Its Lifestyle in the Porcine Large Intestine 1. 1,2. 3 1 1 Matthew I. Bellgard , Phatthanaphong Wanchanthuek , Tom La , Karon Ryan , Paula Moolhuijzen , 1 1 1 1 1 1 Zayed Albertyn , Babak Shaban , Yair Motro , David S. Dunn , David Schibeci , Adam Hunter , Roberto 1 3 3 Barrero , Nyree D. Phillips , David J. Hampson * 1 Centre for Comparative Genomics, Murdoch University, Murdoch, Western Australia, Australia, 2 Faculty of Informatics, Mahasarakham University, Mahasarakham, Thailand, 3 Animal Research Institute, School Veterinary and Biomedical Science, Murdoch University, Murdoch, Western Australia, Australia Abstract Brachyspira hyodysenteriae is an anaerobic intestinal spirochete that colonizes the large intestine of pigs and causes swine dysentery, a disease of significant economic importance. The genome sequence of B. hyodysenteriae strain WA1 was determined, making it the first representative of the genus Brachyspira to be sequenced, and the seventeenth spirochete genome to be reported. The genome consisted of a circular 3,000,694 base pair (bp) chromosome, and a 35,940 bp circular plasmid that has not previously been described. The spirochete had 2,122 protein-coding sequences. Of the predicted proteins, more had similarities to proteins of the enteric Escherichia coli and Clostridium species than they did to proteins of other spirochetes. Many of thes