genetic variations in key microrna processing genes and risk of head and neck cancer a case-control study in chinese population基因变异的关键基因和微处理头颈部癌症的风险在中国人口病例对照研究.pdfVIP

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genetic variations in key microrna processing genes and risk of head and neck cancer a case-control study in chinese population基因变异的关键基因和微处理头颈部癌症的风险在中国人口病例对照研究.pdf

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genetic variations in key microrna processing genes and risk of head and neck cancer a case-control study in chinese population基因变异的关键基因和微处理头颈部癌症的风险在中国人口病例对照研究

Genetic Variations in Key MicroRNA Processing Genes and Risk of Head and Neck Cancer: A Case-Control Study in Chinese Population 1,2. 2,3. 3 4 3 1,2 1,2 Hongxia Ma , Hua Yuan , Zhiyao Yuan , Chenjie Yu , Ruixia Wang , Yue Jiang , Zhibin Hu , 1,2 3 Hongbing Shen , Ning Chen * 1 Department of Epidemiology and Biostatistics, MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China, 2 Section of Clinical Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Centre, Nanjing Medical University, Nanjing, China, 3 Institute of Stomatology, Nanjing Medical University, Nanjing, China, 4 Department of Otorhinolaryngology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China Abstract MicroRNAs (miRNAs) have been reported to play a key role in oncogenesis. Genetic variations in miRNA processing genes and miRNA binding sites may affect the biogenesis of miRNA and the miRNA-mRNA interactions, hence promoting tumorigenesis. In the present study, we hypothesized that potentially functional polymorphisms in miRNA processing genes may contribute to head and neck cancer (HNC) susceptibility. To test this hypothesis, we genotyped three SNPs at miRNA binding sites of miRNA processing genes (rs1057035 in 39UTR of DICER, rs3803012 in 3 9UTR of RAN and rin 39UTR of HIWI) with a case-control study including 397 HNC cases and 900 controls matched by age and sex in Chinese. Although none of three SNPs was significantly associated with overall risk of HNC, rs1057035 in 39UTR of DICER was associated with a