genome analysis of a highly virulent serotype 1 strain of streptococcus pneumoniae from west africa基因组分析的一个高度致命的肺炎链球菌血清型1株西非.pdfVIP

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genome analysis of a highly virulent serotype 1 strain of streptococcus pneumoniae from west africa基因组分析的一个高度致命的肺炎链球菌血清型1株西非.pdf

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genome analysis of a highly virulent serotype 1 strain of streptococcus pneumoniae from west africa基因组分析的一个高度致命的肺炎链球菌血清型1株西非

Genome Analysis of a Highly Virulent Serotype 1 Strain of Streptococcus pneumoniae from West Africa 1 2 3 4 3¤ Tiffany M. Williams , Nicholas J. Loman , Chinelo Ebruke , Daniel M. Musher , Richard A. Adegbola , 2 1 3 Mark J. Pallen , George M. Weinstock *, Martin Antonio 1The Genome Institute, Washington University, St. Louis, Missouri, United States of America, 2 Centre for Systems Biology, University of Birmingham, Birmingham, United Kingdom, 3 Bacterial Diseases Programme, Medical Research Council Laboratories, Banjul, The Gambia, 4 Infectious Diseases Section, Michael E. DeBakey VA Medical Center, Houston, Texas, United States of America Abstract Streptococcus pneumoniae is a leading cause of pneumonia, meningitis, and bacteremia, estimated to cause 2 million deaths annually. The majority of pneumococcal mortality occurs in developing countries, with serotype 1 a leading cause in these areas. To begin to better understand the larger impact that serotype 1 strains have in developing countries, we characterized virulence and genetic content of PNI0373, a serotype 1 strain from a diseased patient in The Gambia. PNI0373 and another African serotype 1 strain showed high virulence in a mouse intraperitoneal challenge model, with 20% survival at a dose of 1 cfu. The PNI0373 genome sequence was similar in structure to other pneumococci, with the exception of a 100 kb inversion. PNI0373 showed only15 lineage specific CDS when compared to the pan-genome of pneumococcus. However analysis of non-core orthologs of pneumococcal genomes, showed