genetics of host response to leishmania tropica in mice – different control of skin pathology, chemokine reaction, and invasion into spleen and liver小鼠基因的宿主反应利什曼虫tropicau2014u2014不同控制皮肤病理、趋化因子反应,入侵脾脏和肝脏.pdfVIP

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genetics of host response to leishmania tropica in mice – different control of skin pathology, chemokine reaction, and invasion into spleen and liver小鼠基因的宿主反应利什曼虫tropicau2014u2014不同控制皮肤病理、趋化因子反应,入侵脾脏和肝脏.pdf

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genetics of host response to leishmania tropica in mice – different control of skin pathology, chemokine reaction, and invasion into spleen and liver小鼠基因的宿主反应利什曼虫tropicau2014u2014不同控制皮肤病理、趋化因子反应,入侵脾脏和肝脏

Genetics of Host Response to Leishmania tropica in Mice – Different Control of Skin Pathology, Chemokine Reaction, and Invasion into Spleen and Liver 1. ´ 1. 1 1 ´ˇ ´ 1 Tetyana Kobets , Helena Havelkova , Igor Grekov , Valeriya Volkova , Jarmila Vojtıskova , ˇ ´ 1 1 1 ´ 2 3 Martina Slapnickova , Iryna Kurey , Yahya Sohrabi , Milena Svobodova , Peter Demant , ´ 1* Marie Lipoldova 1 Laboratory of Molecular and Cellular Immunology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic, 2 Faculty of Science, Charles University, Prague, Czech Republic, 3 Roswell Park Cancer Institute, Buffalo, New York, United States of America Abstract Background: Leishmaniasis is a disease caused by protozoan parasites of genus Leishmania. The frequent involvement of Leishmania tropica in human leishmaniasis has been recognized only recently. Similarly as L. major, L. tropica causes cutaneous leishmaniasis in humans, but can also visceralize and cause systemic illness. The relationship between the host genotype and disease manifestations is poorly understood because there were no suitable animal models. Methods: We studied susceptibility to L. tropica, using BALB/c-c-STS/A (CcS/Dem) recombinant congenic (RC) strains, which differ greatly in susceptibility to L. major. Mice were infected with L. tropica and skin lesions, cytokine and chemokine levels