genetic variation on 9p22 is associated with abnormal ovarian ultrasound results in the prostate, lung, colorectal, and ovarian cancer screening trial第22位9日遗传变异与卵巢超声异常导致前列腺癌、肺癌、直肠癌、卵巢癌筛查试验.pdfVIP

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genetic variation on 9p22 is associated with abnormal ovarian ultrasound results in the prostate, lung, colorectal, and ovarian cancer screening trial第22位9日遗传变异与卵巢超声异常导致前列腺癌、肺癌、直肠癌、卵巢癌筛查试验.pdf

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genetic variation on 9p22 is associated with abnormal ovarian ultrasound results in the prostate, lung, colorectal, and ovarian cancer screening trial第22位9日遗传变异与卵巢超声异常导致前列腺癌、肺癌、直肠癌、卵巢癌筛查试验

Genetic Variation on 9p22 Is Associated with Abnormal Ovarian Ultrasound Results in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial 1 1 2 1 3 Nicolas Wentzensen *, Amanda Black , Kevin Jacobs , Hannah P. Yang , Christine D. Berg , Neil 1 4 5 6 1,2 1 Caporaso , Ulrike Peters , Lawrence Ragard , Saundra S. Buys , Stephen Chanock , Patricia Hartge 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America, 2 Core Genotyping Facility, National Cancer Institute, Rockville, Maryland, United States of America, 3 Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, United States of America, 4 Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, 5 Westat, Rockville, Maryland, United States of America, 6 Oncology Division, Huntsman Cancer Institute, Salt Lake City, Utah, United States of America Abstract Background: A recent ovarian cancer genome-wide association study (GWAS) identified a locus on 9p22 associated with reduced ovarian cancer risk. The single nucleotide polymorphism (SNP) markers localize to the BNC2 gene, which has been associated with ovarian development. Methods: We analyzed the association of 9p22 SNPs with transvaginal ultrasound (TVU) screening results and CA-125 blood levels from participants without ovarian cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO); 1,106 women with adequate ultrasound screening results and available genotyping information were included in the