有哪些信誉好的足球投注网站functional and structural properties of dentate granule cells with hilar basal dendrites in mouse entorhino-hippocampal slice cultures功能和结构性能的齿状颗粒与门的基底树突细胞在小鼠entorhino-hippocampal片文化.pdfVIP
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functional and structural properties of dentate granule cells with hilar basal dendrites in mouse entorhino-hippocampal slice cultures功能和结构性能的齿状颗粒与门的基底树突细胞在小鼠entorhino-hippocampal片文化
Functional and Structural Properties of Dentate Granule Cells with Hilar Basal Dendrites in Mouse Entorhino- Hippocampal Slice Cultures 1. 1. 1 1 1 Denise Becker , Laurent Maximilian Willems , Matej Vnencak , Nadine Zahn , Gerlind Schuldt , 1 2 1 1 Peter Jedlicka , Nicola Maggio , Thomas Deller , Andreas Vlachos * 1 Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe-University Frankfurt, Frankfurt, Germany, 2 Talpiot Medical Leadership Program, Department of Neurology and J. Sagol Neuroscience Center, The Chaim Sheba Medical Center, Tel HaShomer, Israel Abstract During postnatal development hippocampal dentate granule cells (GCs) often extend dendrites from the basal pole of their cell bodies into the hilar region. These so-called hilar basal dendrites (hBD) usually regress with maturation. However, hBDs may persist in a subset of mature GCs under certain conditions (both physiological and pathological). The functional role of these hBD-GCs remains not well understood. Here, we have studied hBD-GCs in mature ($18 days in vitro) mouse entorhino-hippocampal slice cultures under control conditions and have compared their basic functional properties (basic intrinsic and synaptic properties) and structural properties (dendritic arborisation and spine densities) to those of neighboring GCs without hBDs in the same set of cultures. Except for the presence of hBDs, we did not detect major differences between the two GC populations. Furthermore, paired recordings of neighboring GCs with and without hBDs did n
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