functional and transcriptional characterization of human embryonic stem cell-derived endothelial cells for treatment of myocardial infarction功能和转录特征的人类胚胎干细胞内皮细胞治疗心肌梗塞.pdfVIP

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functional and transcriptional characterization of human embryonic stem cell-derived endothelial cells for treatment of myocardial infarction功能和转录特征的人类胚胎干细胞内皮细胞治疗心肌梗塞.pdf

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functional and transcriptional characterization of human embryonic stem cell-derived endothelial cells for treatment of myocardial infarction功能和转录特征的人类胚胎干细胞内皮细胞治疗心肌梗塞

Functional and Transcriptional Characterization of Human Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Myocardial Infarction 1,7 1,2 1 3 1 1 Zongjin Li , Kitchener D. Wilson , Bryan Smith , Daniel L. Kraft , Fangjun Jia , Mei Huang , Xiaoyan 1 4 1 3,5 1,5,6 Xie , Robert C. Robbins , Sanjiv S. Gambhir , Irving L. Weissman , Joseph C. Wu * 1 Department of Radiology and Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine, Stanford, California, United States of America, 2 Department of Bioengineering, Stanford University School of Medicine, Stanford, California, United States of America, 3 Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, United States of America, 4 Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, United States of America, 5 Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, United States of America, 6 Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, California, United States of America, 7 Nankai University School of Medicine, Tianjin, China Abstract Background: Differentiation of human embryonic stem cells into endothelial cells (hESC-ECs) has the potential to provide an unlimited source of cells for novel transplantation therapies of ischemic diseases by supporting angiogenesis and vasculogenesis. However, the endothelial differentiation efficiency of the conventional embryoid body (E