functional and morphological cardiac magnetic resonance imaging of mice using a cryogenic quadrature radiofrequency coil心脏磁共振成像功能和形态的老鼠使用低温交射频线圈.pdfVIP

Functional and Morphological Cardiac Magnetic Resonance Imaging of Mice Using a Cryogenic Quadrature Radiofrequency Coil 1. 1 . 1,2 1 Babette Wagenhaus , Andreas Pohlmann * , Matthias Alexander Dieringer , Antje Els , 1,3 1,3 2 1,3 Helmar Waiczies , Sonia Waiczies , Jeanette Schulz-Menger , Thoralf Niendorf ¨ ´ 1 Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbruck Center for Molecular Medicine, Berlin, Germany, 2 Charite Working Group Cardiac MRI, Experimental and Clinical ´ Research Center and HELIOS Clinics, Berlin, Germany, 3 Experimental and Clinical Research Center, a joint cooperation between the Charite Medical Faculty and the Max- ¨ Delbruck Center for Molecular Medicine, Berlin, Germany Abstract Cardiac morphology and function assessment by magnetic resonance imaging is of increasing interest for a variety of mouse models in pre-clinical cardiac research, such as myocardial infarction models or myocardial injury/remodeling in genetically or pharmacologically induced hypertension. Signal-to-noise ratio (SNR) constraints, however, limit image quality and blood myocardium delineation, which crucially depend on high spatial resolution. Significant gains in SNR with a cryogenically cooled RF probe have been shown for mouse brain MRI, yet the potential of applying cryogeni