gene targeting turns mice into long-distance runners基因打靶把老鼠变成了长跑.pdfVIP

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gene targeting turns mice into long-distance runners基因打靶把老鼠变成了长跑.pdf

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gene targeting turns mice into long-distance runners基因打靶把老鼠变成了长跑

Open access, freely available online Research Digest Synopses of Research Articles Gene Targeting Turns Mice into Endurance training can enhance the and decreased level of specialized type Long-Distance Runners metabolic performance of muscle types, II contractile proteins in the transgenic and now it appears that training can also mice. Interestingly, these same results DOI: 10.1371/journal.pbio.0020322 induce conversion between ﬁ ber types. were seen when naturally occurring Speciﬁ c changes in gene expression (endogenous) PPARδ levels were Have you ever noticed that long- trigger this oxidative ﬁ ber transformation, stimulated in the normal mice (with distance runners and sprinters seem an orally active compound). specially engineered for their This suggests that muscle ﬁ bers sports? One’s built for distance, can be transformed into type the other speed. The ability to I endurance ﬁ bers by simply generate quick bursts of power or activating the endogenou