gene-environment interaction in the onset of eczema in infancy filaggrin loss-of-function mutations enhanced by neonatal cat exposure中间丝相关蛋白基因-环境相互作用在湿疹的发病在婴儿期丧失突变增强新生儿猫接触.pdfVIP

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gene-environment interaction in the onset of eczema in infancy filaggrin loss-of-function mutations enhanced by neonatal cat exposure中间丝相关蛋白基因-环境相互作用在湿疹的发病在婴儿期丧失突变增强新生儿猫接触.pdf

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gene-environment interaction in the onset of eczema in infancy filaggrin loss-of-function mutations enhanced by neonatal cat exposure中间丝相关蛋白基因-环境相互作用在湿疹的发病在婴儿期丧失突变增强新生儿猫接触

PLoS MEDICINE Gene-Environment Interaction in the Onset of Eczema in Infancy: Filaggrin Loss-of-Function Mutations Enhanced by Neonatal Cat Exposure 1* 2 3 1 3 4 Hans Bisgaard , Angela Simpson , Colin N.A. Palmer , Klaus Bønnelykke , Irwin Mclean , Somnath Mukhopadhyay , 1 1 5 2 2 2 Christian B. Pipper , Liselotte B. Halkjaer , Brian Lipworth , Jenny Hankinson , Ashley Woodcock , Adnan Custovic 1 Copenhagen Prospective Studies on Asthma in Childhood, Danish Paediatric Asthma Centre, Copenhagen, University Hospital Gentofte, Copenhagen, Denmark, 2 School of Translational Medicine, University of Manchester, University Hospital of South Manchester National Health Service Foundation Trust, Manchester, United Kingdom, 3 Population Pharmacogenetics Group, Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom, 4 Royal Alexandra Children’s Hospital, Brighton and Sussex Medical School, Brighton, United Kingdom, 5 Asthma and Allergy Research Group, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Scotland, United Kingdom Funding: Copenhagen Study on A B S T R A C T Asthma in Childhood (COPSAC) is funded by research funds. The main funds are: the Lundbeck Foundation; the Pharmacy Foundation of 1991; Background Augustinus Foundation; and the Danish Medical Research Council. Loss-of-function variants in the gene encod