有哪些信誉好的足球投注网站gene regulation and epigenetic remodeling in murine embryonic stem cells by c-myc基因调控和表观遗传改造原癌基因在小鼠胚胎干细胞.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
gene regulation and epigenetic remodeling in murine embryonic stem cells by c-myc基因调控和表观遗传改造原癌基因在小鼠胚胎干细胞
Gene Regulation and Epigenetic Remodeling in Murine Embryonic Stem Cells by c-Myc 1 2 3 2 1 Chin-Hsing Lin , ChenWei Lin , Hisashi Tanaka , Matthew L. Fero , Robert N. Eisenman * 1 Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, 2 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, 3 Department of Molecular Genetics, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America Abstract Background: The Myc oncoprotein, a transcriptional regulator involved in the etiology of many different tumor types, has been demonstrated to play an important role in the functions of embryonic stem (ES) cells. Nonetheless, it is still unclear as to whether Myc has unique target and functions in ES cells. Methodology/Principal Findings: To elucidate the role of c-Myc in murine ES cells, we mapped its genomic binding sites by chromatin-immunoprecipitation combined with DNA microarrays (ChIP-chip). In addition to previously identified targets we identified genes involved in pluripotency, early development, and chromatin modification/structure that are bound and regulated by c-Myc in murine ES cells. Myc also binds and regulates loci previously identified as Polycomb (PcG) targets, including genes that contain bivalent chromatin domains. To determine whether c-Myc influences the epigenetic state of Myc-bound genes, we assessed the patterns of trimethylation of histone H3-K4 and H3-K27 in mES cells containing normal, increased, and reduced levels of c-Myc. Our analysis reveals widespread and surprisingly diverse changes in repressive and activating histone methylation marks both proximal and distal to Myc bind
您可能关注的文档
- from functional genomics to functional immunomics new challenges, old problems, big rewards从功能基因组学、功能immunomics新的挑战,老问题,大的回报.pdf
- from local to global dilemmas in social networks从本地到全球困境的社会网络.pdf
- from molecules to behavior organismal-level regulation of ion channel trafficking从分子到器官层次调节离子通道走私行为.pdf
- from nonspecific dna–protein encounter complexes to the prediction of dna–protein interactions从非特异性dna蛋白质遇到复合物dna蛋白质相互作用的预测.pdf
- from one to many and back again a systemic signal triggers tunicate regeneration从一个和许多系统性信号触发有被膜的再生.pdf
- frequent missense and insertiondeletion polymorphisms in the ovine shadoo gene parallel species-specific variation in prp频繁的错义和insertiondeletion多态性在绵羊的shadoo prp平行种特异的基因变异.pdf
- from pathways databases to network models of switching behavior从路径数据库转换行为的网络模型.pdf
- from oxford to hawaii ecophysiological barriers limit human progression in ten sport monuments从牛津到夏威夷的地步壁垒限制人类发展十运动纪念碑.pdf
- from plants to birds higher avian predation rates in trees responding to insect herbivory从植物到鸟类在树上鸟类捕食率对昆虫取食.pdf
- frequent gain and loss of introns in fungal cytochrome b genes频繁的得失真菌细胞色素b基因的内含子.pdf
- genedistiller—distilling candidate genes from linkage intervals从连杆间隔genedistiller-distilling候选基因.pdf
- gene-environment interaction in the onset of eczema in infancy filaggrin loss-of-function mutations enhanced by neonatal cat exposure中间丝相关蛋白基因-环境相互作用在湿疹的发病在婴儿期丧失突变增强新生儿猫接触.pdf
- gene-disease network analysis reveals functional modules in mendelian, complex and environmental diseases在孟德尔基因-疾病网络分析显示功能模块、复杂和环境的疾病.pdf
- gene–environment interactions at nucleotide resolution在核苷酸基因-环境交互作用的决议.pdf
- gene-gene and gene-environmental interactions of childhood asthma a multifactor dimension reduction approach儿童哮喘的基因基因和gene-environmental交互多因素降维方法.pdf
- gene signatures predict interferon response for ms patients对ms病人基因签名预测干扰素反应.pdf
- gene-network analysis identifies susceptibility genes related to glycobiology in autism基因网络分析确定糖生物学相关的易感基因在孤独症.pdf
- general anesthetics predicted to block the glic pore with micromolar affinity全麻药预测阻止glic孔隙和微摩尔的亲和力.pdf
- general epidemiological parameters of viral hepatitis a, b, c, and e in six regions of china a cross-sectional study in 2007一般病毒性肝炎的流行病学参数a,b,c和e在六个地区的2007年,中国一个横断面研究.pdf
- general intelligence in another primate individual differences across cognitive task performance in a new world monkey (saguinus oedipus)在另一个灵长类动物一般智力的个体差异在认知任务绩效在新世界猴(saguinus俄狄浦斯).pdf
文档评论（0）