有哪些信誉好的足球投注网站from knockouts to networks establishing direct cause-effect relationships through graph analysis从淘汰赛中通过图形分析网络建立直接的因果关系.pdfVIP
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from knockouts to networks establishing direct cause-effect relationships through graph analysis从淘汰赛中通过图形分析网络建立直接的因果关系
From Knockouts to Networks: Establishing Direct Cause- Effect Relationships through Graph Analysis Andrea Pinna, Nicola Soranzo, Alberto de la Fuente* Center for Advanced Studies, Research and Development (CRS4) Bioinformatica, Pula, Italy Abstract Background: Reverse-engineering gene networks from expression profiles is a difficult problem for which a multitude of techniques have been developed over the last decade. The yearly organized DREAM challenges allow for a fair evaluation and unbiased comparison of these methods. Results: We propose an inference algorithm that combines confidence matrices, computed as the standard scores from single-gene knockout data, with the down-ranking of feed-forward edges. Substantial improvements on the predictions can be obtained after the execution of this second step. Conclusions: Our algorithm was awarded the best overall performance at the DREAM4 In Silico 100-gene network sub- challenge, proving to be effective in inferring medium-size gene regulatory networks. This success demonstrates once again the decisive importance of gene expression data obtained after systematic gene perturbations and highlights the usefulness of graph analysis to increase the reliability of inference. Citation: Pinna A, Soranzo N, de la Fuente A (2010) From Knockouts to Networks: Establishing Direct Cause-Effect Relationships through Graph Analysis. PLoS ONE 5(10): e12912. doi:10.1371/journal.pone.0012912 Editor: Mark Isalan, Center for Genomic Regulation, Spain Received April 2, 2010; Accepted July 29, 2010; Published October 11, 2010 Copyright: 2010 Pinna et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, pro
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