from molecules to behavior organismal-level regulation of ion channel trafficking从分子到器官层次调节离子通道走私行为.pdfVIP

Primer 1 From Molecules to Behavior: Organismal-Level Regulation of Ion Channel Trafficking 1 2,3 Eric S. Fortune , Maurice J. Chacron * 1 Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland, United States of America, 2 Department of Physiology, Center for Nonlinear Dynamics, McGill University, Montreal, Canada, 3 Department of Physics, McGill University, Montreal, Canada Transmembrane proteins are critical, not only for cell survival, such as protein synthesis and degradation? Answering this but also for a myriad of physiological functions in multicellular important question will require an integrative approach that organisms. It is therefore necessary to have mechanisms that relates the molecular basis of trafficking to changes in cell regulate the number of these proteins present on the cellular function and behavior. Specialized animal model systems have membrane at any given time. One such mechanism involves historically proven to be useful in such multilevel integrative protein trafficking, or constitutive cycling, in which transmem- studies [17–19]. brane proteins are continuously transferred between a pool located within the endoplasmic reticulum and the membrane surface by Weakly Electric Fishes as a Model System for the shuttle proteins (Figure 1) [1]. The actual number of proteins at Study of Receptor Trafficking the membrane surface is controlled by the rate of exocytosis (i.e., the rate at which proteins are inserted into the membrane) as well Weakly electric fish have a suite of simple ph