有哪些信誉好的足球投注网站a single nucleotide in stem loop ii of 5′-untranslated region contributes to virulence of enterovirus 71 in mice茎环二世的单核苷酸5u2032非翻译地区导致小鼠毒性肠病毒71.pdfVIP
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a single nucleotide in stem loop ii of 5′-untranslated region contributes to virulence of enterovirus 71 in mice茎环二世的单核苷酸5u2032非翻译地区导致小鼠毒性肠病毒71
A Single Nucleotide in Stem Loop II of 59-Untranslated Region Contributes to Virulence of Enterovirus 71 in Mice 1,2 1,2,3 1,2,4 5 1,2,4 Ming-Te Yeh , Shainn-Wei Wang , Chun-Keung Yu , Kuei-Hsiang Lin , Huan-Yao Lei , Ih-Jen Su6, Jen-Ren Wang1,2,6,7* 1The Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan, 2 Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan, 3 Institute of Molecular Medicine, National Cheng Kung University, Tainan, Taiwan, 4 Department of Microbiology and Immunology, National Cheng Kung University, Tainan, Taiwan, 5 Department of Laboratory Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, 6 National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan, Taiwan, 7 Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Tainan, Taiwan Abstract Background: Enterovirus 71 (EV71) has emerged as a neuroinvasive virus responsible for several large outbreaks in the Asia- Pacific region while virulence determinant remains unexplored. Principal Findings: In this report, we investigated increased virulence of unadapted EV71 clinical isolate 237 as compared with isolate 4643 in mice. A fragment 12 nucleotides in length in stem loop (SL) II of 237 5 9-untranslated region (UTR) visibly reduced survival time and rate in mice was identified by constructing a series of infectious clones harboring chimeric 59- UTR. In cells transfected with bicistronic plasmids, and replicon RNAs, the 12-nt fragment of isolate 237 enhanced translational activities and accelerated replication of subgenomic EV71. F
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