有哪些信誉好的足球投注网站a single nucleotide change affects fur-dependent regulation of sodb in h. pylori单个核苷酸变化影响fur-dependent监管sodb幽门螺旋杆菌.pdfVIP
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a single nucleotide change affects fur-dependent regulation of sodb in h. pylori单个核苷酸变化影响fur-dependent监管sodb幽门螺旋杆菌
A Single Nucleotide Change Affects Fur-Dependent Regulation of sodB in H. pylori 1 1 1 2 1 Beth M. Carpenter , Hanan Gancz , Reyda P. Gonzalez-Nieves , Abby L. West , Jeannette M. Whitmire , 2 1 Sarah L. J. Michel , D. Scott Merrell * 1 Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, 2 Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, United States of America Abstract Helicobacter pylori is a significant human pathogen that has adapted to survive the many stresses found within the gastric environment. Superoxide Dismutase (SodB) is an important factor that helps H. pylori combat oxidative stress. sodB was previously shown to be repressed by the Ferric Uptake Regulator (Fur) in the absence of iron (apo-Fur regulation) [1]. Herein, we show that apo regulation is not fully conserved among all strains of H. pylori. apo-Fur dependent changes in sodB expression are not observed under iron deplete conditions in H. pylori strains G27, HPAG1, or J99. However, Fur regulation of pfr and amiE occurs as expected. Comparative analysis of the Fur coding sequence between G27 and 26695 revealed a single amino acid difference, which was not responsible for the altered sodB regulation. Comparison of the sodB promoters from G27 and 26695 also revealed a single nucleotide difference within the predicted Fur binding site. Alteration of this nucleotide in G27 to that of 26695 restored apo-Fur dependent sodB regulation, indicating that a single base difference is at least partially responsible for the difference in sodB regulation observe
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