有哪些信誉好的足球投注网站a novel protein lztfl1 regulates ciliary trafficking of the bbsome and smoothened一种新型蛋白质lztfl1调节bbsome纤毛贩运和波动性.pdfVIP
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a novel protein lztfl1 regulates ciliary trafficking of the bbsome and smoothened一种新型蛋白质lztfl1调节bbsome纤毛贩运和波动性
A Novel Protein LZTFL1 Regulates Ciliary Trafficking of the BBSome and Smoothened 1,2¤ 1,2 1,2 3 1,2 Seongjin Seo , Qihong Zhang , Kevin Bugge , David K. Breslow , Charles C. Searby , Maxence V. Nachury3, Val C. Sheffield1,2* 1 Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa, United States of America, 2 Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America, 3 Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, United States of America Abstract Many signaling proteins including G protein-coupled receptors localize to primary cilia, regulating cellular processes including differentiation, proliferation, organogenesis, and tumorigenesis. Bardet-Biedl Syndrome (BBS) proteins are involved in maintaining ciliary function by mediating protein trafficking to the cilia. However, the mechanisms governing ciliary trafficking by BBS proteins are not well understood. Here, we show that a novel protein, Leucine-zipper transcription factor-like 1 (LZTFL1), interacts with a BBS protein complex known as the BBSome and regulates ciliary trafficking of this complex. We also show that all BBSome subunits and BBS3 (also known as ARL6) are required for BBSome ciliary entry and that reduction of LZTFL1 restores BBSome trafficking to cilia in BBS3 and BBS5 depleted cells. Finally, we found that BBS proteins and LZTFL1 regulate ciliary trafficking of hedgehog signal transducer, Smoothened. Our findings suggest that LZTFL1 is an important regulator of BBSome ciliary trafficking and hedgehog signaling. Citation: Seo S, Zhang Q, Bugge K, Breslow
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