有哪些信誉好的足球投注网站a novel recombinant peste des petits ruminants-canine adenovirus vaccine elicits long-lasting neutralizing antibody response against ppr in goats一种新型小ruminants-canine有害生物重组腺病毒疫苗产生持久的中和抗体的反应对ppr山羊.pdfVIP
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a novel recombinant peste des petits ruminants-canine adenovirus vaccine elicits long-lasting neutralizing antibody response against ppr in goats一种新型小ruminants-canine有害生物重组腺病毒疫苗产生持久的中和抗体的反应对ppr山羊
A Novel Recombinant Peste des Petits Ruminants-Canine Adenovirus Vaccine Elicits Long-Lasting Neutralizing Antibody Response against PPR in Goats 1,2 2,4 2,3 2 2 2 Junling Qin , Hainan Huang , Yang Ruan , Xiaoqiang Hou , Songtao Yang , Chengyu Wang , 2 2 2 2 1,2 Geng Huang , Tiecheng Wang , Na Feng , Yuwei Gao *, Xianzhu Xia * 1 College of Animal Science and Veterinary Medicine, Agricultural Division, Jilin University, Changchun, People’s Republic of China, 2 Veterinary Institute, Academy of Military Medical Sciences, Changchun, People’s Republic of China, 3 College of Animal Science and Technology, Jilin Agricultural University, Changchun, People’s Republic of China, 4 Academy of Animal Science and Veterinary Medicine of Jilin Province, Jilin, Changchun, People’s Republic of China Abstract Background: Peste des petits ruminants (PPR) is a highly contagious infectious disease of goats, sheep and small wild ruminant species with high morbidity and mortality rates. The Peste des petits ruminants virus (PPRV) expresses a hemagglutinin (H) glycoprotein on its outer envelope that is crucial for viral attachment to host cells and represents a key antigen for inducing the host immune response. Methodology/Principal Findings: To determine whether H can be exploited to generate an effective PPRV vaccine, a replication-competent recombinant canine adenovirus type-2 (CAV-2) expressing the H gene of PPRV (China/Tibet strain) was constructed by the in vitro ligation method. The H expression cassette, including the h
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