a novel immune evasion strategy of candida albicans proteolytic cleavage of a salivary antimicrobial peptide一个新颖的白色念珠菌的免疫逃避策略蛋白水解唾液抗菌肽的乳沟.pdfVIP
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a novel immune evasion strategy of candida albicans proteolytic cleavage of a salivary antimicrobial peptide一个新颖的白色念珠菌的免疫逃避策略蛋白水解唾液抗菌肽的乳沟
A Novel Immune Evasion Strategy of Candida albicans: Proteolytic Cleavage of a Salivary Antimicrobial Peptide 1,2 3,4 3 5,6 1,2 Timothy F. Meiller , Bernhard Hube , Lydia Schild , Mark E. Shirtliff , Mark A. Scheper , Robert 7¤ 1 1,8 Winkler , Amy Ton , Mary Ann Jabra-Rizk * 1 Department of Oncology and Diagnostic Sciences, University of Maryland – Baltimore, Baltimore, Maryland, United States of America, 2 Marlene and Stewart Greenbaum Cancer Center, University of Maryland Medical System, Baltimore, Maryland, United States of America, 3 Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knoell-Institute (HKI), Jena, Germany, 4 Friedrich Schiller University, Jena, Germany, 5 Department of Microbial Pathogenesis, Dental School, University of Maryland – Baltimore, Baltimore, Maryland, United States of America, 6 Department of Microbiology and Immunology, School of Medicine, University of Maryland – Baltimore, Baltimore, Maryland, United States of America, 7 Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knoell-Institute (HKI), Jena, Germany, 8 Department of Pathology, School of Medicine, University of Maryland – Baltimore, Baltimore, Maryland, United States of America Abstract Oropharyngeal candidiasis is an opportunistic infection considered to be a harbinger of AIDS. The etiologic agent Candida albicans is a fungal species commonly colonizing human mucosal surfaces. However, under conditions of immune dysfunction, coloni
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