a laminin g-egf-laminin g module in neurexin iv is essential for the apico-lateral localization of contactin and organization of septate junctions一层粘连蛋白g-egf-laminin g模块在第四neurexin contactin apico-lateral本地化的至关重要和有隔膜的连接组织.pdfVIP

A Laminin G-EGF-Laminin G Module in Neurexin IV Is Essential for the Apico-Lateral Localization of Contactin and Organization of Septate Junctions 1 1¤ 1,2 2 1,2 Swati Banerjee , Raehum Paik , Rosa E. Mino , Kevin Blauth , Elizabeth S. Fisher , Victoria J. 3 1 1,2,4,5 Madden , Alan S. Fanning , Manzoor A. Bhat * 1 Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America, 2 Curriculum in Neurobiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America, 3 Microscopy Services Laboratory, Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America, 4 UNC-Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America, 5 Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America Abstract Septate junctions (SJs) display a unique ultrastructural morphology with ladder-like electron densities that are conserved through evolution. Genetic and molecular analyses have identified a highly conserved core complex of SJ proteins consisting of three cell adhesion molecules Neurexin IV, Contactin, and Neuroglian, which interact with the cytoskeletal FERM domain protein Coracle. How these individual proteins interact to form the septal arrays that create the paracellular barrier is poorly understood. Here, we