有哪些信誉好的足球投注网站a novel magnetic nanoparticle drug carrier for enhanced cancer chemotherapy一种新型磁性纳米药物载体增强癌症化疗.pdfVIP
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a novel magnetic nanoparticle drug carrier for enhanced cancer chemotherapy一种新型磁性纳米药物载体增强癌症化疗
A Novel Magnetic Nanoparticle Drug Carrier for Enhanced Cancer Chemotherapy 1,5. 3. 2 4 2 4 Xu Chao , Zhuoli Zhang , Lili Guo , Jingjing Zhu , Mingli Peng , Alphonsus J. M. Vermorken , Wim J. M. Van de Ven4, Chao Chen1,2, Yali Cui1,2* 1The College of Life Sciences, Northwest University, Xi’an, China, 2 National Engineering Research Center for Miniaturized Detection Systems, Xi’an, China, 3 Department of Radiology, Northwestern University, Chicago, Illinois, United States of America, 4 Laboratory for Molecular Oncology, Department of Human Genetics, K.U. Leuven, Leuven, Belgium, 5 The College of Basic Medical Science, Shaanxi University of Chinese Medicine, Xianyang, China Abstract Background: Magnetic nanoparticles (NPs) loaded with antitumor drugs in combination with an external magnetic field (EMF)-guided delivery can improve the efficacy of treatment and may decrease serious side effects. The purpose of this study was 1) to investigate application of PEG modified GMNPs (PGMNPs) as a drug carrier of the chemotherapy compound doxorubicin (DOX) in vitro; 2) to evaluate the therapeutic efficiency of DOX-conjugated PGMNPs (DOX-PGMNPs) using an EMF-guided delivery in vivo. Methods: First, DOX-PGMNPs were synthesized and the cytotoxicity of DOX-PGMNPs was assessed in vitro. Second, upon intravenous administration of DOX-PMGPNs to H22 hepatoma cell tumor-bearing mice, the DOX biodistribution in different organs (tissues) was measured. The antitumor activity was evaluated using different treatment strategies such as DOX- PMGPNs or DOX-PMGPNs with an EMF-guided delivery (DOX-PGMNPs-M). Results: The relative tumor volumes in DOX-PGMNPs-M, DOX-PGMNPs, and DOX groups were 5.46 61.48, 9.2261.51, and 14.861.64, respe
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