a hypomorphic vasopressin allele prevents anxiety-related behaviorhypomorphic抗利尿激素等位基因防止焦虑性行为.pdfVIP
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a hypomorphic vasopressin allele prevents anxiety-related behaviorhypomorphic抗利尿激素等位基因防止焦虑性行为
A Hypomorphic Vasopressin Allele Prevents Anxiety- Related Behavior 1. 1. 1 1 1¤ Mirjam Bunck , Ludwig Czibere *, Charlotte Horvath , Cornelia Graf , Elisabeth Frank , Melanie S. 1 1 ¨ 1 1 1 ¨ 1 Keßler , Chris Murgatroyd , Bertram Muller-Myhsok , Mariya Gonik , Peter Weber , Benno Putz , Patrik 2 3 2 1 1,4 Muigg , Markus Panhuysen , Nicolas Singewald , Thomas Bettecken , Jan M. Deussing , Florian 1 1 1 Holsboer , Dietmar Spengler , Rainer Landgraf 1 Max Planck Institute of Psychiatry, Munich, Germany, 2 University of Innsbruck, Innsbruck, Austria, 3 Affectis Pharmaceuticals, Martinsried, Germany, 4 Helmholtz Zentrum, Institute of Developmental Genetics, Munich/Neuherberg, Germany Abstract Background: To investigate neurobiological correlates of trait anxiety, CD1 mice were selectively bred for extremes in anxiety-related behavior, with high (HAB) and low (LAB) anxiety-related behavior mice additionally differing in behavioral tests reflecting depression-like behavior. Methodology/ Principal Findings: In this study, microarray analysis, in situ hybridization, quantitative real-time PCR and immunohistochemistry revealed decreased expression of the vasopressin gene (Avp) in the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei of adult LAB mice compared to HAB, NAB (normal anxiety-related behavior) and H
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