a kernel for open source drug discovery in tropical diseases一个内核的开源药物发现的热带疾病.pdfVIP

A Kernel for Open Source Drug Discovery in Tropical Diseases ´1,2 2 3 3¤ 4 5 Leticia Ortı , Rodrigo J. Carbajo , Ursula Pieper , Narayanan Eswar , Stephen M. Maurer , Arti K. Rai , 6 7 2 3 1 Ginger Taylor , Matthew H. Todd , Antonio Pineda-Lucena , Andrej Sali *, Marc A. Marti-Renom * ´ ´ 1 Structural Genomics Unit, Bioinformatics and Genomics Department, Centro de Investigacion Prıncipe Felipe, Valencia, Spain, 2 Structural Biology Laboratory, Medicinal ´ ´ Chemistry Department, Centro de Investigacion Prıncipe Felipe, Valencia, Spain, 3 Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, and California Institute for Quantitative Biosciences, University of California San Francisco, San Francisco, California, United States of America, 4 Gould School of Law, University of Southern California, Los Angeles, California, United States of America, 5 School of Law, Duke University, Durham, North Carolina, United States of America, 6 The Synaptic Leap, San Ramon, California, United States of America, 7 School of Chemistry, University of Sydney, Sydney, New South Wales, Australia Abstract Background: Conventional patent-based drug development incentives work badly for the developing world, where commercial markets are usually small