a burst-based “hebbian” learning rule at retinogeniculate synapses links retinal waves to activity-dependent refinementburst-basedu201chebbianu201d学习规则在视网膜电波活动依赖性细化retinogeniculate突触联系.pdfVIP

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a burst-based “hebbian” learning rule at retinogeniculate synapses links retinal waves to activity-dependent refinementburst-basedu201chebbianu201d学习规则在视网膜电波活动依赖性细化retinogeniculate突触联系.pdf

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a burst-based “hebbian” learning rule at retinogeniculate synapses links retinal waves to activity-dependent refinementburst-basedu201chebbianu201d学习规则在视网膜电波活动依赖性细化retinogeniculate突触联系

PLoS BIOLOGY A Burst-Based ‘‘Hebbian’’ Learning Rule at Retinogeniculate Synapses Links Retinal Waves to Activity-Dependent Refinement *¤ Daniel A. Butts , Patrick O. Kanold, Carla J. Shatz Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, United States of America Patterned spontaneous activity in the developing retina is necessary to drive synaptic refinement in the lateral geniculate nucleus (LGN). Using perforated patch recordings from neurons in LGN slices during the period of eye segregation, we examine how such burst-based activity can instruct this refinement. Retinogeniculate synapses have a novel learning rule that depends on the latencies between pre- and postsynaptic bursts on the order of one second: coincident bursts produce long-lasting synaptic enhancement, whereas non-overlapping bursts produce mild synaptic weakening. It is consistent with ‘‘Hebbian’’ development thought to exist at this synapse, and we demonstrate computationally that such a rule can robustly use retinal waves to drive eye segregation and retinotopic refinement. Thus, by measuring plasticity induced by natural activity patterns, synaptic learning rules can be linked directly to their larger role in instructing the patterning of neural connectivity. Citation: Butts DA, Kanold PO, Shatz CJ (2007) A burst-based ‘‘Hebbian’’ learning rule at retinogeniculate synapses links retinal waves to activity-dependent refinement. PLoS Biol 5(3): e61. doi:10.1371/journal.pbio.0050061 Introduction for development [18,19]. However, several recent studies have manipulated ret