以sortasea为靶点的表皮葡萄球菌感染干预机制初探..docVIP

以sortase A为靶点的表皮葡萄球菌感染干预机制 谭超12 王君3 邹黎黎* 1 三峡大学第一临床医学院宜昌市中心人民医院中国湖北宜昌443002三峡大学医学院中国湖北宜昌443002摘要：近年来，随着植入式医疗装置使用量的增加，相关临床感染不断上升，严重威胁到患者的生命健康。表皮葡萄球菌是引起这些感染的“罪魁祸首”，其主要依赖在植入物的表面形成生物膜而致病。以LPXTG结构域为共同标志的细胞壁锚定蛋白在表皮葡萄球菌生物膜形成过程中发挥着重要作用，ortase A在革兰氏阳性菌中功能的保守性及重要性，以ortase A作为靶点来表皮葡萄球菌的感染 关键词：表皮葡萄球菌 生物膜 转肽酶A 项目基金：国家自然科学基金；三峡大学人才科研启动基金KJ2011B051） *通讯作者：邹黎黎1982-），女，重庆人，三峡大学医学院讲师，博士，主要从事与免疫相关研究；E-mail: zoulili@ 作者简介：谭超，男（1981-），三峡大学免疫学在读硕士，检验主管技师，主要从事分子免疫学研究；E-mai: yczxyytanchao@ The Intervention Mechanism of Staphylococcus epidermidis based on sortase A Chao Tao1, 2, Jun Wang3, Lili Zou2* 1 Three gorges university first clinical medical school/Yichang center peoples hospital, Yichang 443002,?China 2 Key Laboratory for Pathogenic Microorganism, Medical School of China Three Gorges University, 8 Daxue Road, Yichang 443002,?China Abstract: With the increasing use of the medical implantable medical device, the related clinical infections are rising rapidly in recent years, which are serious threats to the health of the patients. As the main factor of these infections, Staphylococcus epidermidis depends on formation of biofilm in the surface of the implants to cause diseases. The cell wall anchored proteins of S. epidermidis, which have LPXTG domain as the common sign, are play important roles in the process of biofilm formation. As the key factor of anchoring LPXTG proteins to the peptidoglycan of S. epidermidis cell wall, sortase A was conservative in Gram positive bacteria, which can be used as the perfect target to intervene the S. epidermidis infection. We reviewed the S. epidermidis virulence factors and conservative and important function of sortase A, and discussed our study on the relationship between S. epidermidis infection and sortase A, which can help provide the theoretical basis for controlling S. epidermidis infection. Keywords: Staphylococcus epidermidis biofilm sortase A S