385例癫痫患者血药浓度监测分析.pdfVIP

jk ALi、A 2ACADEMIAE MEDICINAE XUZHOU 2008，28(1) ·63· 385例癫痫患者血药浓度监测分析 王来成，李相涛，王 涛 (徐州医学院附属医院药剂科，江苏 徐州 221002) 摘要：目的 通过血药浓度监测了解常规应用抗癫痫药患者的血药浓度情况，为临床合理用药提供参考。方 法 采用荧光偏振免疫法对385例癫痫患者进行血药浓度监测。结果 监测446例次中，低于有效血药浓度202 例次，占45．3％，高于有效血药浓度34例次，占7．6％。结论 癫痢患者常规经验用药的血药浓度个体差异较 大，血药浓度监测对个体化用药具有重要意义。 关键词：抗癫痫药；血药浓度；荧光偏振免疫法 中图分类号：R969．3；R749．1 7 文献标识码：B 文章编号：1000—2065(2008)01—0063～02 Monitoring of serum drug concentration in 385 epileptic patients WANG Laicheng，LI Xiangtao，WANG Tao (Department of Pharmacy，Affiliated Hospital of Xuzhou Medical College，Xuzhou，Jiangsu 221002，China) Abstract：0bjective To investigate the situation in the clinical use of antiepileptie drugs(AEDs)SO as to ration— alize their clinical use．Methods The sealm concentration of AEDs in 385 epileptic patients was determined by fluores— cence polarization immunoassay．Results Analysis of the 446 tests performed in the study revealed that the sealm level was below the effective serum drug concentrations in 202(45．3％)tests，and above the effective concentration in 34 (7．6％)tests．Conclusion Since the range of effective AEDs level is rather narrow and the patients react to the drug differently，it is important to monitor serum drug concentrations to individualize the dosage of AEDs for certain patients． Kew words：antiepileptic drugs；serum drug concentration；fluorescence polarization immunoassay 癫痫(epilepsy)是大脑神经元反复发作性异常 病程最短1个月，最长40余年。治疗过程中一般使 放电导致中枢神经系统暂时功能失常的一种慢性疾 用常规推荐剂量。298例患者单药治疗，占77．4％， 病，现阶段不能完全根治，需进行长达3～5年或以 其中：VPA 202例，占52．5％；CBZ 51例，占13．3％； 上的抗癫痫药(antiepileptic drugs，AED )系统治 PHT 21例，占5．5％；PB 24例，占6．2％。87例联 疗。目前，丙戊酸(valproic acid，VPA)、卡马西平 合用药，占22，6％。 (carbamazepine，CBZ)、苯妥英(