不同剂量国产布托啡诺术后静脉镇痛效果比较.pdfVIP

实用医药杂志2008年03月第25卷第03期Prac J Med＆Pharm．Vol 25，2008—03 No．03 · 273· 临床研究 不同剂量国产布托啡诺术后 · 论 著· 静脉镇痛效果比较 车润平 费圣强 葛 蕤 王庆新 张 欣 庞秀丽 王言高 魏 朴 陈家友 (401医院麻醉科。山东青岛 266100) 【摘 要】 目的 评价不同剂量国产布托啡诺用于术后静脉持续自控镇痛(PC1A)疗效及药物不良反应 发生牢。方法 ASA I～Ⅱ级剖腹手术与骨科手术患者174例，划分为三组，分别给予布托啡诺0．15mg／kg (I组)、O．20mg／kg(II组)和O．25m~kg(1lI组)用于术后PC1A治疗，镇痛持续时间至术后48h。结果 镇痛 效果Ⅲ组II组I组( O．01)，而不良反应发生人数I、Ⅱ组 无明显差异(尸O．05)，Ⅲ组患者不良反应 发生人数则明显多于I、Ⅱ组 (P0．05)，60岁患者不良反应发生牢耍 著高于同组青中年患者 (P O．01)。结论 布托啡诺镇痛效果与用药剂量成正相关，不良反应发生牢与用药剂量及患者年龄相关，建 议术后PCIA用药剂量宜从小剂量(O．15mg／kg)开始。 、 【关键词】布托啡诺 术后镇痛 静脉镇痛 不良反应 【中图分类号】R614．1 I文献标识码l A Clinical comparison on postoperative intravenous anesthetic effects and adverse reactions of domestic butorphanol at different dosages CHE Run-ping，FEI SHeng—qiang，GE Rui，et a1． Department of Anesthesiology，No．40 1 Hospital of PLA，Qingdao 266 1 00，China 【Abstract】 0bjective To evaluate the post—operative anesthetic effects and the incidence rates of adverse reactions of butorphanol at different dosages in patient undergoing PCIA．Methods The 174 patients which had underwent open abdominal surgery and orthopaedic surgery were randomly divided in to three groups．Group 1 was administered with butorphanol 0．1 5mg／kg．group II O．2mg／kg．group llI O．25m~kg．Results There were significantly differences in anesthetic effects among three groups O．O1)，ie group llIgroupⅡgroup I(P0．O1)．There were not differences in incidence rates of adverse reactions between group I and groupⅡ (PO．05)，but group 111 were significantly higher than group I and group II(尸lO．05)，the patients over 60yr old were higher than other patients in same group(PO．O 1)． Conclusion De anesthetic effects of butorphanol is positively correlated to pharmie dosage，but the incid