比索洛尔对充血性心力衰竭患者促炎性和抗炎性细胞因子的影响_沈丽娟.pdfVIP

DOI:10.13748/ki.issn1007-7693.2011.02.017 ·医院药学 · 比索洛尔对充血性心力衰竭患者促炎性和抗炎性细胞因子的影响 1 2* (1.南京中医药大学无锡附属医院，江苏 无锡 214002 ；2.江苏大学附属武进医院心内科，江苏 常州 213002) 摘要：目的 (congestive heart failureCHF) 方法 100 CHF ()50 ()-6(IL-6)-α(TNF-α)-10(IL-10) 12 12 IL-6IL-10 TNF-α 6 min (six-minute hall walk test6 WT)结果 (P0.01) IL-6TNF-α(P0.05)IL-10 IL-6 (P0.05) 6 WT 6 WT 结论 CHF ()CHF 关键词-6 -10 -α 中图分类号R972.1 文献标志码A 文章编号1007-7693(2011)02-0170-04 Effect of Bisoprolol on Pro-inflammatory and Anti-inflammatory in Patients with Congestive Heart Failure 1 2* SHEN Lijuan , HE Guoping (1.Nanjing University of Chinese Medicine Affiliated Wuxi Hospital, Wuxi 214002, China; 2.Department of Cardiology, Jiangsu University Affiliated Wujin Hospital, Changzhou 213002, China) ABSTRACT: OBJECTIVE To investigate the levels of serum concentrations of interleukin-6(IL-6), tumor necrosis factor-alpha(TNF-α) and interleukin-10(IL-10) in patients with congestive heart failure (CHF), and to evaluate the beneficial effects of bisoprolol on the above variables, cardiac function and exercise endurance. METHODS One hundred patients with CHF(CHF group) and fifty healthy physical examinees(control group) were selected. The serum levels of IL-6, IL-10 and TNF-α were measured. Patients with CHF were divided randomly into conventional treatment group and bisoprolol group (ro