ALL临床研究effects of biolo cal response modifiers on childhood ALL being in remission after chemotherapy.pdfVIP

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ALL临床研究effects of biolo cal response modifiers on childhood ALL being in remission after chemotherapy.pdf

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R~at~~edPhurt~racother{ 1991)45,113-I 16 113 8 Elsevier,Parts ffects of biolo cal response modifiers on e~i~d~~~ being in remission after c~e~~t~era~y* K Kawa’, S Konishi2, G Tsujino’, S Mabuchi3 ‘Department of PerEotrics. Osaka University Hospirat, I-I -50 Fukushima-ku.Osaka 553 ‘The Second Department of Internal Medicine. Children’s Medical Cmter of xa City, Ua ‘~epart,~eat of Hernutolo~~Oaco~#~~Kobe Cblidren’s Hospirat, Kobe. Japun ~u~rna~y - Of 125 children with acute ~ymphabiastic Ieukemia (ALL), who bad been in continwous mrn~ssia~ for three years on c~emotberapy, 108 patients received biological response modifiers (By) such as Bestatin. N-CWS, OK-432 and/or PSK in order to prevent relapse after treatment suspension, Prom 20 patients who were treated with PSK, 6 relapsed within 13 months. This rapse rate was quite similar to the rate observed with those children who were off therapy (4 relapses in 17 patients within 13 months). In contrast to these 37 patients, only 3 out of 31 patients who received Bestatin @ c 0.05) and 8 out of 57 patients who received N-CWS or OK-432 relapsed. Based on these findings, BRMs used in the present study seems to be effective to prevent relapse of leukemia among childhood ALL who have electively stopped chemotherapy. Bestatin I biologica! response modifiers / ALL Rurn6 - Effets des m~~fjeateurs de la rwse immunitaire SW Q LAL de I’enhtnt en riZmism aprs c~~rni~t~~- rapie. Pa