脂质代谢紊乱患者血清脂蛋白氧化易感性的研究_张春妮.pdfVIP

OI: 10. 16571/j .cnki . 1008 -8199.2001.03.003 · 196· 　 14　 3 Vol. 14　No. 3 　2001 6 Journal of Medical Postgraduates Jun. 2001 脂质代谢紊乱患者血清脂蛋白氧化 易感性的研究 张春妮,　李　克,　许跃龙,　庄一义 (, 210002) : 　 目的: ( H L) ( L L)。 　方法: 45( CRF)、 33 ( MIS)、 33 ( ) 53 2( )( , , ) ,( ) CI M V L L L L H L TBARS , A234nm, (44) 。 　结果: V L L TBARS, MIS( , P 0. 001); MIS M L L、 CI M H L TBARS; V L L、 L L , M ; H L; H L L L , CRF M IS。　结论: ,。 : 　;　;　;　 : 　 446. 1　　　: 　 　　:　 1008-8199(2001)03-0196-04 R A Comparison of the susceptibil ity of serum l ipoproteins to oxidation and the eff ects - of high density l ipoprotein against oxidative stress in patients with lipid turbulence ZHANG Chun-ni, LI Ke, XU Yue-long, ZHUANG Yi-yi (Cen ter of M ed ica l Labora tory S cience , J inling Hosp ita l , N anj ing 210002, J iang su , Ch ina ) : 　 : Abstract Obj ect ives To comparethe susceptibility of serum lipoproteins to oxidation and the ef- fects of high-density lipoprotein on oxidative stress in patients with lipid turbulence.　Methods: VL L, L L and H L were isolated using sequential ultracentrifugation from serum of patients ( ) ( = 45) , ( ) ( = 33) , with chronic renal failure CRF n myocardial infarction survivor MIS n cere- bral infarction(CI) (n= 33) , type 2 diabetes mellitus( M) (n = 53) and normal individuals (n = 44). The degree of lipid peroxidation was estimated using the thiobarbituric acid-reactive sub- stances (