痴呆患者血清和脑脊液中炎前和抗炎细胞因子的变化论文.docVIP

　　痴呆患者血清和脑脊液中炎前和抗炎细胞因子的变化论文 李龙宣，赵斌，许志恩，邢孔鸯，唐荣华 【关键词】 痴呆；白介素1β；白介素6；肿瘤坏死因子α；白介素1受体拮抗剂 Changes of pro and antiinflammatory cytokines in serum and cerebrospinal fluid of patients entias 【Abstract】 AIM: To observe the serum and cerebrospinal fluid (CSF) levels of the proinflammatory cytokines, interleukin1 β (IL1β), interleukin6 (IL6), tumor necrosis factor α (TNFα), and the antiinflammatory cytokine, interleukin1 receptor antagonist (IL1ra) in patients entias and normal controls and to investigate their clinical meanings. METHODS: A total of 70 cases of patients entias at the Department of Neurology in our hospital and Peoples Hospital of Taishan City from September 2003 to August 2005 ers disease (AD) patients, 15 mixed dementia (MD) patients and 25 vascular dementia (VD) patients. The serum and CSF levels of IL1β, IL6, TNFα and IL1ra in the patients entias and the controls easured using ELISA. RESULTS: pared to the controls, the levels of TNFα in CSF in the patients entias e extent (P 0.05 or P 0.01). The differences bet levels of IL1β, IL6, TNFα and IL1ra entias in parison levels of the cytokines. CONCLUSION: The changes of pro and antiinflammatory cytokines in the brain might be the factors of the neuropathological damage in AD, VD and MD. 【Keyentia; interleukin1β; interleukin6; interleukin1 receptor antagonist; tumor necrosis factor α 【摘要】 目的：研究炎前和抗炎细胞因子在不同痴呆患者血清和脑脊液中的变化并探讨其临床意义. 方法：200309/200508我院和台山市人民医院神经科就诊的70例老年痴呆患者作为观察对象，其中阿尔茨海默病（AD）30例、混合性痴呆（MD）15例、血管性痴呆（VD）25例. 用夹心式酶联免疫吸附法测定各组老年人血清和脑脊液中白介素1β（IL1β），白介素6（IL6），肿瘤坏死因子α（TNFα）和白介素1受体拮抗剂（IL1ra）的水平. 结果：各痴呆组患者脑脊液中TNFα的水平较正常老年人有不同程度升高.freelers disease, AD）患者脑内的神经病理损伤过程，并在这方面作了大量的研究工作. 但同时研究处于不同老年期痴呆患者生前脑内炎前和抗炎细胞因子表达的报道罕见. 本文系统研究了不同老年期痴呆患者，包括AD，血管性痴呆（vascular dementia, VD），混合性痴呆（mixed dementia, MD）患者血清与脑脊液（cerebrospinal fluid, CSF）中炎前和抗炎细胞因子的变化，现报道如下. 1对象和方法 1.1对象200309/200508我院和台山市人民医院神经科住院患者. 简易精神状态检查量表（MMSE） 24分初筛有痴呆纳入观察对象，按照美国精神疾病诊断及统计手册第四版（DSMⅣ）标准诊断痴呆. AD组30例，均符合美国神经病学、语言障碍和卒中阿尔茨海默病和相关疾病学会（NINCDSADRDA）很可