Vol.61,No32014403–419创新.PDFVIP

Vol. 61, No 3/2014 403–419 on-line at: www.actabp.pl Review Role of the host genetic variability in the influenza A virus susceptibility 1 2,3 1,4 Ana Carolina Arcanjo *, Giovanni Mazzocco *, Silviene Fabiana de Oliveira , Dariusz Plewczynski2,4,5,6 and Jan P. Radomski2,7* 1Laboratório de Genética, Departamento de Genética e Morfologia, Instituto de Ciências Biológicas, Universidade de Brasília, Brasília, DF, Brazil; 2 Interdisciplinary Center for Mathematical and Computational Modeling, Warsaw University, Warsaw, Poland; 3 Institute of Computer Science, 4 Polish Academy of Sciences, Warsaw, Poland; The Jackson Laboratory for Genomic Medicine, c/o University of Connecticut Health Cent- er; Farmington, CT USA; 5Yale University, New Haven, CT, USA; 6Center for Innovative Research, Medical University of Bialystok, Poland; 7 Institute of Biotechnology and Antibiotics, Warsaw, Poland The aftermath of influenza infection is determined by Schmitz et al., 2005; Jayasekera et al., 2007; Koyama et al., a complex set of host-pathogen interactions, where 2007; Throsby et al. 2008; Ichinohe et al., 2009; Sabbah et genomic variability on both viral and host sides influenc- al., 2009; Kreijtz et al., 2011; Zhou et al., 2012; Henn et es the final outcome. Although there exists large body