数学仿真研究光漂白对光动力治疗鲜红斑痣的影响顾瑛.pdfVIP

DOI牶牨牥牣牨牫牬牳牥牤j牣issn牨牥牥牫牠牴牬牫牥牣牪牥牥牭牣牥牭牣牥牥牨 2005 10 14 5　C in J LaserM ed Surg, October 2005, Vol 14, No.5 数学仿真研究光漂白对光动力治疗鲜红斑痣的影响 1 1 1 2 2 顾瑛 　黄乃艳 　刘凡光 　程刚 　钟秋海 　、、, 、、 , , 。 　M onte Carlo;; Fick ;; Lamber-t B eer 。 　, , 。 , , 。 　。 　;　;　;　;　 :　R454.2;N945.12　　　:　A　　　:　1003 - 9430(2005)05 -0273 - 06 Influence of Photobleachni g ni Photodynam ic Treatment on PortW ine Stani s by MathematicalSmi ulatoi n 1 1 1 2 2 GU Y ing, HUANG Na-iyan, LIU an-guang, CHENG Gang, ZHONG Q iu-hai 1 .D eparmt ent of LaserM ed icine, ChinesePLA GeneralHospital, B eijing 100853, C ina　2 .D epartm en t of Automa-t ic Control, Beijing Institu te of Technolog ABSTRACT Obj ective　T roug estab lis ing m at em aticalm odel of t e distribu tion of laser, p otosensitizer, oxygen and t eir interaction relation- s ip, smi ulating t e generation of singlet oxygen in blood vesse,l epiderm is and derm is, analyzing t e effects of various factors relating w it p otobleac ing on t e generation of singlet oxygen, to explore t e action and value of p otobleac ing in p otodynam ic t erapy on port w ine stains. M ethods　T e distribution of laserw as formu lated by Monte Carlo m odel.T e distribution of p otosensitizer in vessels by p arm acok-i netics. T e d iffuseness of p otosensitizer and oxygen in tissuesw as formu lated by t e F ick s law.T e p otobleac ing was described by second order k inetic reaction includ ing t e content of oxygen in tissues. T e generation of singlet oxygen in every tissue w as calculated by t e law of Lam ber-t Beer and quan tum yields of singlet oxygen. R esu lts　T e increase in singlet oxygen in vesselsw allwasm ore t an t at in ot er norm al tissues by t e reason of p otobleac ingw en 　:　1.(, 100853)　2. 　:　(1959 ～　), , , 、、、, 。