时辰诱导化疗序贯同步放化疗治疗局部晚期鼻咽癌患者临床探究.docVIP

时辰诱导化疗序贯同步放化疗治疗局部晚期鼻咽癌患者临床探究 　　摘要：目的 研究时辰诱导化疗序贯同步放化疗治疗局部晚期鼻咽癌患者的临床效果。方法 选择60例局部晚期鼻咽癌患者，患者均予以时辰诱导化疗序贯同步放化疗治疗，观察患者的治疗效果及化疗期间的不良反应。结果 ?T导化疗的有效率86.7%，诱导化疗及序贯同步放化疗的有效率为95.0%，化疗后3个月的有效率为100.0%。化疗期间的不良反应以骨髓抑制和消化道反应机肝肾功损害为主。随访期间患者的生率为86.7%。结论 TPF方案时辰诱导化疗序贯同步化疗治疗局部晚期鼻咽癌的疗效好，可延长患者中位无进展生存时间，且不会增加不良反应 关键词：时辰诱导化疗；鼻咽癌；局部 Clinical Study of Sequential Chemotherapy Combined with Chrono Chemotherapy for Locally Advanced Nasopharyngeal Carcinoma LUO Liang-zhi （Department of Oncology，Qionglai Medical Center Hospital，Qionglai 611530，Sichuan，China） Abstract：Objective To study the clinical effect of induction Chrono chemotherapy followed by concurrent chemoradiotherapy in the treatment of patients with locally advanced nasopharyngeal carcinoma.Methods 60 cases of patients with locally advanced nasopharyngeal carcinoma，patients received induction Chrono chemotherapy followed by concurrent chemoradiotherapy，adverse reactions were observed during treatment and chemotherapy.Results Induction chemotherapy was 86.7%，induction chemotherapy and sequential concurrent chemoradiotherapy efficiency was 95.0%， 3 months after the chemotherapy efficiency was 100.0%.Adverse reactions during chemotherapy on bone marrow suppression and gastrointestinal reaction machine damage to liver and kidney function.During the follow-up，the curative effect rate was 86.7%.Conclusion TPT regimen is a good combination of sequential chemotherapy in the treatment of locally advanced nasopharyngeal carcinoma，which can prolong the median survival time of patients without any adverse reaction. Key words：Chrono chemotherapy；Nasopharyngeal carcinoma；Local 鼻咽癌主要是指发生在鼻咽顶部和侧壁的恶性肿瘤，在我国具有较高的发病率，由于鼻咽部的解剖位置较为隐蔽，在发病早期其临床症状不典型，随着病情的进展可逐渐出现涕血、鼻出血、耳鸣、听力下降、头痛及颈部包块等症状，因症状明显而去医院就诊时已经发展为中晚期，失去了最佳的治疗时间[1]。晚期的鼻咽癌预后效果较差，放化疗及同步化疗等姑息疗法是常见治疗手段，目前临床常用的治疗方案是诱导化疗并行同步放化疗的综合疗法，在本次的研究中笔者将分析时辰诱导化疗序贯同步放化疗治疗局部晚期鼻咽癌的效果，结果如下： 1 资料与方法 1.1一般资料 60例局部鼻咽癌晚期患者为我院2011～2013年收治，其中男42例，女18例，患者年龄20～70岁，平均年龄（50.2±5.0）岁，病理类型：非角化未分化型20例，非角化分化型10例