缺氧诱导因子-1α在大鼠血栓闭塞性脉管炎模型中的表达论文.pdfVIP

山西医科大学硕士论文 and after the sham operation group, modeling the expression of HIF- 1α in serum was no significant difference (P 0.05), the serum after the modeling HIF-1α expression in the rapid increaseof 1 daygroup, 3days reduced slightly, then gradually decreased, but higher than the level of the sham group, of which between 1 day and 3 days, one week and 2 weeks between 3 weeks and 4 weeks was no significant difference between (P 0.05), remaininginthemodel werestatistically significantcomparison(P0.05). 3. Immunohistochemical results: HIF-1α protein in the sham group and in the model of bilateral lower expression in the contralateral muscle, the muscle tissue of the affectedside in the model is highly expressed in the model affected side of the expression of HIF-1α average gray value were statistically significant compared with the healthy side (P 0.05), of which 1 day, 3 days group, the average gray value of the minimum, no significant difference between the two groups (P 0.05), compared with other manufacturing modules There were significant differences (P 0.05), 1 week, 2 weeks expression was no significant difference between the two groups (P 0.05), than the other in the model were significantly different (P 0.05), 3 weeks 4 weeks no significant difference between the two groups (P 0.05), than the other in the model were statistically significant(P0.05). Conclusion: Conclusion: CCoonncclluussiioonn:: 1. Using the femoral artery injection of sodium laurate produced TAO rat model, the method is simple, a high successratemodelingcanbeusedforscientific researchonTAO. 2. In this study, developed the initial lesions in the early thromboangiitis obliterans, serum and tissues showed high expression of hypoxia inducible factor-1α, as the disease advances are rapidly declining, this may be patients with TAO and thus failed to establish an effect