缺血后处理和还原型谷胱甘肽对大鼠下肢缺血再灌注损伤的影响.pdfVIP

山西医科大学硕士学位论文 The results were measured by mean ±SD，analysis of variance was used to test fo r differences on SPSS13.0，least significant difference test (LSD-t) for multiple comparis on. Results: After I/R,the MDA contents was significantly increased while the SOD ac tivity was significantly decreased as compared to the S group(P0.05). The MDA contents was significantly lower while the SOD activity was significantl y higher in IPo, GSH, and IPo+GSH groups as compared with I/R group(P0.05). The damage induced by I/R were significantly ameliorated. The MDA contents was significantly lower while the SOD activity was significantl y higher in IPo+GSH group compared with IPo and GSH groups(P0.05). There were n o significant difference in the indexes among the IPo group and GSH group （P0.05 ）. Conclusion: IPo, GSH and Ipo+GSH can reduce the risk of limb dysfunction and injury associated with renal I/R injury in rats through enhancement SOD activity. IPo, GSH and IPo+GSH can protect the limbs against ischemia-reperfusion injury in rats and IPo+GSH is more effective. Key words: reperfusion injury, ischemic postconditioning, reduced glutathione, limb