从普通肝素到磺达肝癸钠肝素类抗凝药物研发历程.pptVIP

* Dr. Irving S. Wright, the first doctor to use an anticoagulant to treat the blood clots that can cause heart attacks and strokes, died on Dec. 8 at his home in Manhattan. He was 96. Dr. Wright, a cardiologist and former president of the American Heart Association, retired in 1968 from the New York Hospital-Cornell Medical Center. In 1938, Dr. Wright, then a professor of clinical medicine at the New York Post-Graduate Medical School of Columbia University, was gravely ill for months because of thrombophlebitis, which involves the formation of a blood clot. After he recovered, he looked for a way to treat a patient whose life was also threatened by thrombophlebitis. Such patients were likely to die because the blood clots could move to the lungs and cause pulmonary embolisms. Dr. Wright treated the patient with an experimental natural anticoagulant called heparin, isolated from animal organs. At the time, heparin had recently been purified at the University of Toronto but had not yet been used to treat a patient, a colleague, Dr. Richard L. Mueller, said in 1995 in the journal Clinical Cardiology. The condition of Dr. Wrights patient improved in two weeks. Therapy with heparin and other coagulants is now standard throughout the world in cases of thrombophlebitis, pulmonary embolism and heart surgery. In 1960, Dr. Wright received the prestigious Albert Lasker Award from the American Heart Association for his study of the use of anticoagulants in 800 heart attack victims. Dr. Wright was born in Manhattan and received his B.A. in 1923 from Cornell and his M.D. in 1926 from the Cornell University Medical College in Manhattan. He joined New York Hospital-Cornell Medical Center in 1946. He was an author of You and Your Heart (Random House, 1950) and was a co-author of 11 other books, mainly on circulatory problems. Dr. Wright was president of the American Heart Association in the 1950s, the American College of Physicians and the American Geriatric Society. In 1979