骨肉瘤中c_kit的表达及其临床意义.pdfVIP

# 470# 临床与实验病理学杂志 J Clin Exp P athol 2009 O ct; 25( 5) c-kit 1, 2 2 1 1 1 1 魏 红 , 李劲松 , 姜晓刚 , 燕春艳 , 崔 文, 王 旭 : c-k it, c-k it, EnV ision c-kit 4 0 , , c-k it 1117 c-kit 6215% ( 25/4 0) ; c-k it, c-k it 38 SSCP , c-k it , c-k it, : ; ; c-kit ( CD 117) ; c-k it; : R 738 1; R 394 3 : A : 1001- 7399 ( 2009) 05 - 0470 - 03 Expression and significance of c-kit in osteosarcoma 1, 2 2 1 1 1 1 W E I H ong , L I J in-song , JIANG X iao-gang , YAN Chun-yan , CU I W en , W ANG Xu 1 2 ( D ep ar tm ent of P athology, J in ing M ed ical Un iv ers ity, J in ing 2720 13, Ch ina D ep artmen t of P athology, Q ilu H osp ital, Shandong U- n iv er sity, J inan 25 0012, Ch ina) Abstract: Purpose T o investigate the express ion of c-kit in hum an osteo sarcom a and the ir re la tionsh ip s w ith c linicop atho log ica l pa- ram eters and progno stic va lu e and then to determ ine m utationa l statu s o f exon s 11 and 17 o f c-k it gene w h ich prov ide theo re tica l founda- tion for predicting progno sis and targeted the rapy M ethods The express ion o f c-kit prote in w as de tected m easured in 40 hum an con- ventional osteosarcom a by mi m unoh istochem istry and its re lation ship to prognosis w as ana lyzed statistically The m utation of c-k it in ex- on s 11 and 17 w as determ ined by SSCP R esults The expression ra te of c-kit prote in in conventiona l osteosarcom