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Initial Experience of Applying TWIST-Dixon With Flexible View Sharing in Breast DCE-MRI.pdf
Original Study
Initial Experience of Applying TWIST-Dixon With Flexible View Sharing in Breast DCE-MRI
Yuan Le,1 Hal D. Kipfer,1 Dominik M. Nickel,2 Randall Kroeker,2 Brian M. Dale,2 Stephanie P. Holz,1 Elisabeth Weiland,2 Chen Lin1
Abstract
Time-resolved angiography with stochastic trajectories sequence was modi?ed with ?exible view sharing and ?exible echo time Dixon for breast dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI). Our initial experience showed that it provided potentially valuable information on early tumor enhancement characteristics and maintained excellent image quality in postcontrast enhancement in breast DCE-MRI, which allowed more optimized spatial and temporal resolution in clinical breast imaging. Introduction: We developed a new fast imaging technique with ?exible time-resolved angiography with stochastic trajectories (TWIST) view sharing to achieve variable temporal resolution and with ?exible echo time Dixon to achieve robust fat suppression and to evaluate its application in breast dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI). Materials and Methods: The TWIST-Dixon technique was improved with more ?exible view sharing and echo times (TWIST-Dixon-Flex). In a dynamic series, each measurement can be separately prescribed as “full,” “partial,” or “center-only.” The spatial and temporal resolution can then be adjusted throughout the measurements to match the dynamic characteristics of contrast enhancement at different phases. The potential advantages of TWIST-Dixon-Flex were evaluated with 18 clinical breast DCE MRI cases. A mixed-effects analysis of variance (ANOVA) was performed to compare the image quality with that of the conventional images. Results: The ANOVA showed that the quality of postcontrast TWIST-Dixon-Flex images was signi?cantly higher than that of the conventional images. The TWIST-Dixon-Flex technique also provided the capability to detect differences in rapid contrast uptake from different reg
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