丙戊酸钠联合拉莫三嗪治疗不同类型儿童癫痫的临床观察.docVIP

丙戊酸钠联合拉莫三嗪治疗不同类型儿童癫痫的临床观察 　　[摘要] 目的 探讨不同类型儿童癫痫患者采取丙戊酸钠联合拉莫三嗪治疗的临床效果。 方法 选取小儿难治性癫痫患者107例，根据癫痫分型进行分组，其中部分发作型（PS）44例，部分发作继发全面发作型（SGS）31例，全面发作型（GS）24例，Lennox Gastaut综合征（LGS）8例，均给予丙戊酸钠联合拉莫三嗪口服治疗，观察治疗效果。 结果 SGS患者临床完全控制率最高，而LGS型患者临床控制率最低；GS患者临床恶化率最高；LGS患者总有效率最高，其次是SGS患者，PS和GS患者有效率相对较低。经过治疗，各种类型癫痫患者月平均发作频次较治疗前均有明显降低（P0.05）。14例（13.08%）患儿出现不良反应，未予处理，自行缓解。 结论 丙戊酸钠联合拉莫三嗪治疗不同类型的小儿难治性癫痫均可以取得较好的效果，且安全性良好。 　　[关键词] 丙戊酸钠；拉莫三嗪；小儿癫痫 　　[中图分类号] R742.1 [文献标识码] A [文章编号] 1674-4721（2013）11（b）-0076-02 　　Observation of clinical effect of sodium valproate combined with lamotrigine in treatment of children with different types of epilepsy 　　ZHAO Ya 　　Department of Neurology，People′s Hospital of Taoyuan County in Hunan Province， Taoyuan 415700，China 　　[Abstract] Objective To observe the clinical effect of sodium valproate combined with lamotrigine in treatment of patients with different types of epilepsy. Methods 107 children with intractable epilepsy were selected and divided into four groups. There were 44 cases with PS， 31 cases with SGS， 24 cases with GS， and 8 cases with LGS. All patients were treated with sodium valproate combined with lamotrigine， and the treatment effect was observed. Results The patients with SGS had the highest clinical control rate， and the patients with LGS had the lowest clinical control rate. The patients with GS had the highest clinical deterioration rate. The patients with LGS had the highest total effective rate， followed by the patients with SGS. And the effective rate of patients with PS and GS was low. After treatment， monthly average seizure frequency of all patients reduced evidently compared with that before treatment. The differences were all significant （P0.05）. There was 14 children （13.08%）with adverse reactions， and alleviate by themselves without treatment. Conclusion Sodium valproate combined with lamotrigine in treatment of children with different types of epilepsy can not only achieve good effect， but also is safe. 　　[Key words] Sodium