Neuroprotection against Aβ25–35-induced apoptosis by Salvia miltiorrhiza extract in SH-SY5Y cells》.pdfVIP

Neurochemistry International 75 (2014) 89–95 Contents lists available at ScienceDirect Neurochemistry International journal homepag e: /locate/nci Neuroprotection against Ab25–35-induced apoptosis by Salvia miltiorrhiza extract in SH-SY5Y cells Huimin Yu a,1, Lihua Yao b,1, Hongzu Zhou c,1, Sichang Qu a, Xianghai Zeng a, Delong Zhou a, Yulian Zhou a, Xinglin Li a, Zhicheng Liu c,⇑ a Department of Pathogenic Biology Immunology, Medical College, Shenzhen University, Shenzhen, Guangdong 518060, PR China b School of Life Science, Jiangxi Science Technology Normal University, Nanchang, Jiangxi 330013, PR China c Department of Pharmacy, SZ Hospital of Traditional Chinese Medicine, Shenzhen, Guangdong 518020, PR China a r t i c l e i n f o a b s t r a c t Article history: The neurotoxicity of b-amyloid protein (Ab) contributes significantly to the pathogenesis of Alzheimer’s Received 28 February 2014 disease (AD), and hence the attractive therapeutic strategies focusing on the modulation of Ab-induced Received in revised form 9 May 2014 neurotoxicity are warranted. The present study aims to investigate the neuroprotection and underlying Accepted 4 June 2014 mechanisms by which Salvia miltiorrhiza Bunge (Lamiaceae) extract (SME) protects against Ab25–35- Available online 13 June 2014 induced apoptosis in SH-SY5Y cells. 2 h Pre-treatment of SH-SY5Y cells with SME (0.01, 0.1 or 0.2 mg raw herb/ml) concentration-dependently attenuated Ab25–35-induced cell death, a