Matrine suppresses proliferation and induces apoptosis in human cholangiocarcinoma cells through suppression of JAK2STAT3 signaling》.pdfVIP

Pharmacological Reports 67 (2015) 388–393 Contents lists available at ScienceDirect Pharmacological Reports jou r nal h o mep ag e: w ww .elsevier .co m/loc ate/p h arep Original research article Matrine suppresses proliferation and induces apoptosis in human cholangiocarcinoma cells through suppression of JAK2/STAT3 signaling a a a,* a b a a Nanmu Yang , Feng Han , Hong Cui , Jinxi Huang , Tao Wang , Yi Zhou , Jinxue Zhou a Department of Hepatopancreatobiliary Surgery, The Affiliated Tumor Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China b Department of Anesthesia, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China A R T I C L E I N F O A B S T R A C T Article history: Background: Constitutive activation of signal transducer and activator of transcription 3 (STAT3) Received 19 August 2014 signaling contributes to apoptosis resistance in cholangiocarcinoma. The aim of this study is to check Received in revised form 21 October 2014 whether matrine, an alkaloid isolated from traditional Chinese herb Sophora flavescens ait, can exert Accepted 21 October 2014 cytotoxic effects against cholangiocarcinoma cells via inactivation of STAT3 signaling. Available online 5 November 2014 Methods: Mz-ChA-1 and KMCH-1 ch