Neuropilin-2 mediates lymphangiogenesis of colorectal carcinoma via a VEGFCVEGFR3 independent signaling》.pdfVIP

Cancer Letters 358 (2015) 200–209 Contents lists available at ScienceDirect Cancer Letters journal homepage: /locate/canlet Original Articles Neuropilin-2 mediates lymphangiogenesis of colorectal carcinoma via a VEGFC/VEGFR3 independent signaling Juan-Juan Ou a,1, Xing Wei a,1, Yuan Peng a, Lin Zha a, Rong-Bin Zhou a, Hang Shi c, Qi Zhou a,b,*, Hou-Jie Liang a,** a Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China b Department of oncology, FuLing Central Hospital, Chongqing 408000, China c Department of Biology, Georgia State University, Atlanta, GA 30303, USA A R T I C L E I N F O A B S T R A C T Article history: Lymphangiogenesis critically contributes to the lymphatic metastasis of colorectal carcinomas (CRCs), Received 4 September 2014 but the underlying mechanism of CRC lymphangiogenesis remains largely elusive. We have previously Received in revised form 17 December demonstrated that Semaphorin-3F (SEMA3F) is critically involved in CRC metastasis, and the receptor 2014 of SEMA3F, neuropilin-2 (NRP2), originally described as an axon guiding chemorepulsant implicated in Accepted 19 December 2014 nerve development, has been suggested in promoting lymphangiogenesis via acting as an obligate co- receptor of VEGFR3 cooperatively enhancing the activity of VEGF-C. Our present study revealed that in Keywords: Focal adhesion kinase colorectal carcinomas, NRP2 expression levels