Involvement of Relish gene from Macrobrachium rosenbergii in the expression of anti-microbial peptides》.pdfVIP

Developmental and Comparative Immunology 52 (2015) 236–244 Contents lists available at ScienceDirect Developmental and Comparative Immunology journal homepage: /locate/dci Involvement of Relish gene from Macrobrachium rosenbergii in the expression of anti-microbial peptides Yan-Ru Shi a, Min Jin b, Fu-Tong Ma a, Ying Huang a, Xin Huang a, Jin-Ling Feng a, Ling-Ling Zhao a, Yi-Hong Chen c, Qian Ren a,* a Jiangsu Key Laboratory for Biodiversity Biotechnology and Jiangsu Key Laboratory for Aquatic Crustacean Diseases, College of Life Sciences, Nanj ing Normal University, 1 Wenyuan Road, Nanjing 210046, China b State Key Laboratory Breeding Base of Marine Genetic Resource, Third Institute of Oceanography, SOA, Xiamen 361005, China c MOE Key Laboratory of Aquatic Product Safety/State Key Laboratory of Biocontrol, School of Marine Sciences, Sun Yat-sen University, Guangzhou, China A R T I C L E I N F O A B S T R A C T Article history: Relish is an NF-kB transcription factor involved in immune-deficiency (IMD) signal pathway. In this study, Received 10 April 2015 a Relish gene (MrRelish) was identified from Macrobrachium rosenbergii. The full length of MrRelish com- Revised 18 May 2015 prises 5072 bp, including a 3510 bp open reading frame encoding a 1169 bp amino acid protein. MrRelish Accepted 20 May 2015 contains a Rel homology domain (RHD), a nucleus localization signal, an IκB-like domain (6 ankyrin repeats), Available online 27 May 2015 and a death domain. Phylogenetic analysis showed that