Involvement of the sodium–calcium exchanger 3 (NCX3) in ziram-induced calcium dysregulation and toxicity》.pdfVIP

NeuroToxicology 45 (2014) 56–66 Contents lists available at ScienceDirect NeuroToxicology Involvement of the sodium–calcium exchanger 3 (NCX3) in ziram-induced calcium dysregulation and toxicity J. Jin a,b, A.J. Lao a, M. Katsura a, A. Caputo c, F.E. Schweizer c,d, S. Sokolow a,d,e,f,* a UCLA School of Nursing, Los Angeles, CA 90095, USA b Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, PR China c Department of Neurobiology, UCLA School of Medicine, Los Angeles, CA 90095, USA d UCLA Brain Research Institute, USA e UCLA Center for the Advancement of Gerontological Nursing Sciences, USA f UCLA Clinical and Translational Science Institute, USA A R T I C L E I N F O A B S T R A C T Article history: Ziram is a dimethyldithiocarbamate fungicide which can cause intraneuronal calcium (Ca2+) Received 11 September 2014 dysregulation and subsequently neuronal death. The signaling mechanisms underlying ziram-induced Accepted 22 September 2014 Ca2+ dyshomeostasis and neurotoxicity are not fully understood. NCX3 is the third isoform of the Available online 2 October 2014 2+ sodium–calcium exchanger (NCX) family and plays an important role in regulating Ca homeostasis in excitable cells. We previously generated a mouse model deficient for the sodium–calcium exchanger 3 Keywords