In vitro and in situ evaluation of herb–drug interactions during intestinal metabolism and absorption of Baicalein》.pdfVIP

Journal of Ethnopharmacology 141 (2012) 742–753 Contents lists available at SciVerse ScienceDirect Journal of Ethnopharmacology j o u rn al h omepage: w w w. elsev /locate/jethpharm In vitro and in situ evaluation of herb–drug interactions during intestinal metabolism and absorption of Baicalein Yui Kau Fong a , Chen Rui Li a , Siu Kwan Wo a , Shu Wang a , Limin Zhou a , Li Zhang a , Ge Lin b , Zhong Zuo a,∗ a School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region b School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region a r t i c l e i n f o a b s t r a c t Article history: Ethnopharmacological relevance: Baicalein (B), a bioactive flavone isolated from the root of a traditional Received 2 February 2011 Chinese medicinal herb Scutellaria baicalensis Georgi, was found to undergo extensive intestinal Phase II Received in revised form 10 August 2011 metabolism during its absorption process. Compounds sharing the same metabolic pathways with B or Accepted 21 August 2011 being inhibitors of enzymes UGT and SULT are expected to interfere with the metabolism of B leading Available online 26 August 2011 to alteration of the absorption of B. The present study aims to identify potential intestinal absorption and metabolism interactions between B and four selected compounds