Interventional Value of Total Flavonoids from Rhizoma Drynariae on Cathepsin K,a Potential Target of Osteoporosis.pdfVIP

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Interventional Value of Total Flavonoids from Rhizoma Drynariae on Cathepsin K,a Potential Target of Osteoporosis.pdf

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Interventional Value of Total Flavonoids from Rhizoma Drynariae on Cathepsin K,a Potential Target of Osteoporosis.pdf

· 556· REVIEW I■nt■erVenti0ionaI■V●■aI■UeOt●-IOt■aI■F一I■aVOnOI■a■ST一rOm H^n■J●ZOm a DrynariaeonCathepsinK，aPotentialTargetOfOSteOpOrOSiS SHIXiao·lin(史晓林)，LIUKang(刘康)，andWULian-guo(吴连国) ABSTRACT Osteoporosis，thesixthmostcommondiseaseintheworld。isbringingincreasinglyseriousharm topeoples‘health．CathepsinK，whichplaysanimportantroleinboneresorption，isapotential协rgetinthe treatmentofosteoporosis．Totalflavonoids，theactiveingredientsin开hizomaDrynariae。haveshownobvious therapeuticeffectonosteoporosis．1npreviousstudies．itwaspresumedthatthemechanism forthetherapeutic effectwasthroughinhibitingtheexpressionofCathepsinK．However，therearestilJnodetaliedreportsonsome keyissuessuchasthespecificinhibitoryresultsoftotaIflavonoidsonCathepsinKandthepathwayofinhibition andsoon．BasedonpreviousstudiesontotaIflavonoidsfr0m 开hizomaDrynariae．thepathwayfortheeffectof totalflavonoidsinhibitingCathepsinKandtheirinterventionaIvalueonCathepsinKwereanalyzedinthispaper． sOastoexploretheinterventionalfeasibilityandvalueoftotalflavonoidsin尺hizomaDrynariaeonCathepsinK． KEYWORDS CathepsinK，RhizomaDrynara／e，flavonoid，osteoporosis Withtheagingtrendofpopulationsworldwide， morestudiesonbothofthesehavebeenreported． the incidencerateofosteoporosisand／orfracture Thisarticlefocuseson the relationship between hasbeenincreasingrapidly，whichhascontributed totalflavonoidsandCathepsinK．Additionally，the to serious threatsto SOCiety and the healthof prospectsandcurrentproblemsinthetreatmentof middle-agedand elderlypeople．Chinahasalready osteoporosisarediscussed． entered theaging society，and theprevalence rateofosteoporosishasincreasedyearbyyear． StudiesonTotalFlavOnOidsfrom Rhizoma Osteoporosisisthesixthmostcommondiseaseinthe DrynariaejntheTreatmentofOsteoporosis world]【J_Theprevalenceratesofelderlyosteoporosis