中药益糖康胶囊的药代动力学研究_吕悦.pdfVIP

第 28卷 第 10期 Vol. 28 N o. 10 2 0 10年 10月 CH INESE ARCH IVES OF TRAD IT OI NAL CH INESE M ED CI INE ct. 2 0 1 0 1 2 2 吕 悦,石 岩 , 杨宇峰 ( 1., 116021; 2. , 110847) : 目的: 对益糖康胶囊在家兔体内的药代动力学特 进行初步研究, 为益糖康胶囊的进 一步的研究和 临床应用提供依据建立家兔血浆内盐酸小檗碱的含量测定方法, 研究灌胃给药后, 盐酸小檗碱在家兔体内的药 代动力学规律方法:采用高效液相色谱法 (HPLC)测定中药益糖康胶囊中主要成分盐酸小檗碱在血浆中随时 间变化的浓度变化, 并据此描绘盐酸小檗碱在兔体内的药物代谢 - 时间曲线结果: 对家兔予中药益糖康灌胃 后,益糖康中盐酸小檗碱能迅速被吸收,达峰时间短, 吸收速度快, 消除速度快其含量在 5m in内达到高峰, 之后 盐酸小檗碱的含量随时间推移而迅速降低, 2h后盐酸小檗碱含量降到最低 :益糖康;盐酸小檗碱; 药代动力学; 高效液相色谱法 : R285. 5 : A : 1673- 7717( 2010) 10- 2212- 03 Pharm acok inetics of Y i- Tang- K ang Capsu le 1 2 2 LU Yue , SH IYan, YANG Yu-feng ( 1. Dalian Second PeoplesHospital, Dalian 116021, Liaoning, China; 2. LiaoningUniversity ofTCM, Shenyang 110847, Liaoning, China) Abstrac:t O bj ectiv e: The purpose of this study is to establish a quantitative measurement for berberine hydrochloride in cony blood plasma after feedw ith Y i-Tang- K ang and the pharmacokineticswas studied using thismethod. M ethod: The concentration ofberberine hydrochloride in the plasmawas assayed by theHPLCmethod. Then according to the result to describe the arcuation of pharmacokinetics.R esult: A fter feed rabbitwithY i-T ang- K ang, the berberine hydrochloride can be ingest rapidly. The contents of berberine hydrochloride in the plasma ismaxlmum in fivem inutes.W ith tmi e past, the contents of berberine hydrochloride is reduce. It is reachm inmi um levelat two hours after feed. Key w ords: Y i- Tang- Ka