脑转移瘤瘤周水肿相关分子生物学因素研究进展.pdfVIP

534 中国肿瘤临床2014年第41卷第8期 Chin J Clin Oncol 2014,Vol.41,No.8 · · 综 述 脑转移瘤瘤周水肿相关分子生物学因素研究进展* ① ① ② ③ ③ 高 佳 刘彦慧 阎 玲 陈小岑 综述 赵路军 审校 摘要 脑转移瘤瘤周水肿指脑转移肿瘤周围脑实质内水分的异常增多，是影响患者生活质量和治疗疗效的关键因素之一， 其发生机制复杂，影响因素众多。可能与血管内皮生长因子及其受体、水通道蛋白-4、金属基质蛋白酶-9、白细胞介素-6、乏氧诱 导因子及其他分子生物学因素有关，上述分子生物学因素的深入研究可以为瘤周水肿的防治、监测、治疗及预后提供依据。瘤周 水肿的治疗除传统的脱水治疗外，相关分子生物学因素的运用可以为其提供新的途径和方向，其中水通道蛋白-4激动剂或拮抗 剂，血管内皮生长因子受体拮抗剂已逐步在临床中得到初步应用。本文就脑转移瘤瘤周水肿相关分子生物学因素进行综述。 关键词 脑转移瘤 瘤周水肿 分子生物学 研究进展 doi:10.3969/j.issn.1000-8179 Research progress on peritumoral edema-related molecular biology factors of the metastasis tumor of brain 1 1 2 3 3 Jia GAO , Yanhui LIU , Ling YAN , Xiaocen CHEN , Lujun ZHAO Correspondence to: Yanhui LIU; E-mail: yh_liu888@163.com 1Department of Nursing, Tianjin University of Traditional Chinese Medicine, Tianjin 300193; 2Department of Nursing, 3Depart- ment of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Can- cer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin 300060, China This work was supported by a grant from the Tianjin Key Problem-Tackling Project for Cancer Therapy (No. 12ZCDZSY 15900) Abstract Peritumoral edema (PTE) of the metastasis tumor of brain (MTB) refers to the abnormal increase of moisture in the surrounding cerebral parenchyma of the brain tumor. The mechanism of PTE occurrence of MTB is complicated, and the influencing factors are diverse. PTE is one of the key factors that affect patient survival and cure. Researchers from China and overseas believe that it may be related to the expression of the vascular endothelial growth factor (VEGF) or VEGF receptor, aquaporin-4 (AQP-4), matrix metalloprot