匹多莫德佐治儿童大叶性肺炎支原体肺炎的疗效评价.pdfVIP

匹多莫德佐治儿童大叶性肺炎支原体肺炎的疗效评价

董健;吕响红;刘伟;江忠

【摘要】Objective:Toobservetheclinicaleffectsofpidomodeinthe

treatmentoflobarMycoplasmapneumoniaepneumonia(MPP)in

children,andevaluateitseffectoncellularimmunefunction.

Methods:Forty-fourchildrenwithlobarMPPwererandomlydividedinto

groupAandgroupB,and30healthychildrenweresetascontrolgroup.

GroupBweretreatedwithazithromycin(10mg·kg-1·d-1eachtime)for3

coursesoftreatmemt,andthegroupAweretreatedwithazithromycin

combinedwithpidotimod(0.4g/d)for2months.ThelevelsofT

lymphocytesubsetsinthreegroupbeforetreatmentandafter2monthsof

treatmentweredetectedusingflowcytometry,andtheclinicaleffect

betweengroupAandBwascompared.Results:Beforetreatment,the

serumlevelsofCD3+,CD4+andCD4+/CD8+inlobarMPPgroup

significantlydecreased,andthelevelofCD8+increasedcomparedwith

thecontrolgroup(P0.01).Aftertreatment,theserumlevelsofCD3+,CD4

+andCD4+/CD8+ingroupAsignificantlyincreasedcomparedwith

beforetreatment(P0.01),andthedifferenceofwhichingroupBbetween

beforeandaftertreatmentwasnotstatisticallysignificant(P0.05).After

treatment,thedifferencesoftheserumlevelsofCD3+,CD4+andCD4+

/CD8+betweengroupAandgroupBwerestatisticallysignificant(P0.

01),andthedifferenceofthelevelofserumCD8+intwogroupsbetween

beforeandaftertreatmentwasnotstatisticallysignificant(P0.05).From

thebeginningoftreatmenttofollowfor6months,theclinicalcurative

effectingroupAwasbetterthanthatingroupB(P0.01).

Conclusions:Cellularimmunefunctiondisorderexistsinlobar

MPP,pidotimodcanregulatetheimmunebalance,strengthen

immunity,andimprovetheclinicalcurativeeffectinchildrenwithlobar

MPP.%目的:观察匹多莫德佐治儿童大叶性肺炎支原体肺炎的临床效果,评价其对细

胞免疫功能的影响.方法:选取48例大叶性MPP患儿随机分为A、B组,同时选取门

诊同期体检的健康儿童30名为对照组.B组予以常规阿奇霉素(10mg·